What is Antiglaucoma drug?

Antiglaucoma drugs form the basis of medical management of glaucoma. These drugs are pharmacological agents which reduce the intra-ocular pressure either by reducing aqueous humor production or by increasing the outflow of this fluid from the intra-ocular compartments.

What is the first choice of Antiglaucoma drug?

a)Timolol- is one of the most popular and prescribed antiglaucoma agents, as a first-line drug in most forms of open angle glaucoma and ocular hypertension [2]. It reduces the production of aqueous humor by acting on the ciliary body, inhibiting beta 1 and beta 2 adrenergic receptors.

Which Antiglaucoma agent is administered orally?

Acetazolamide and methazolamide are the most commonly used oral CAI agents. Dichlorphenamide is another agent in this group. Oral CAIs begin to act within 1 hour of administration, with maximal effect within 2 to 4 hours.

What is the mechanism of action of timolol?

The mechanism of action of timolol is probably the reduction of the formation of aqueous humor in the ciliary body in the eye. It was the first beta blocker approved for topical use in treatment of glaucoma in the United States (1978).

What are the oral medications for glaucoma?

Examples include: Dorzolamide (Trusopt®) Brinzolamide (Azopt®) Acetazolamide (Diamox®): an oral medication….Examples include:

  • Timolol (Timoptic XE Ocumeter® and Timoptic®)
  • Levobunolol (Betagan®)
  • Carteolol (Ocupress®)
  • Metipranolol (OptiPranolol®)
  • Betatoxol (Betoptic®)

What is a normal eye pressure?

While the average eye pressure is approximately 15 mm Hg (millimeters of mercury), the range of normal eye pressure is much larger. About 90 percent of people will fall between a pressure of 10 and 21. Even so, this does not mean that if you have a pressure of 22 or higher it is abnormal.

How do anti-glaucoma drugs work?

Anti-glaucoma Drugs (Ocular Pharmacology) Mechanisms of action of anti glaucoma agents Chief therapeutic measure is to lower IOP to the target level either by o Reducing aqueous production in the ciliary body o Promoting aqueous humour outflow through the trabecular meshwork o Promoting aqueous humour outflow via the uveoscleral pathway.

What is the mode of action of anti glaucoma drugs?

Mode of action of anti glaucoma drugs Beta blocker-decrease aqueous secretion Miotics -increase trabecular outflow Adrenergic agonist-decrease aqueous secretion Prostaglandin-increase trabecular and uveaoscleral outflow Carbonic anhydrase inhibitor-decrease aqueous secretion Summary 62.

What are the available drugs for glaucoma?

8. Open-angle Glaucoma (OAG) 9. Available drugs • β- adrenergic blockers: Timolol, Betaxolol and Levobunolol • α- adrenergic agonists: Dipivefrine, Apraclonidine and Brimonidine • PG analogues: Latanoprost, Travoprost and Bimatoprost • Carbonic anhydrase inhibitors: Acetazolamide and dorzolamide • Miotics: Pilocarpine and Physostigmine 10.

What is the best alpha agonist for glaucoma?

Clonidine  Synthesized in the early 1960s, Clonidine was the first alpha agonist used systemically and topically for glaucoma Available in  Dichlorophenyl aminoimidazoline  Isoglaucon 0.125%, 0.2%, 0.5% 41.