What is the pathogenesis of malaria?

PATHOGENESIS. Severe malaria is predominantly caused by Plasmodium falciparum because of its ability to induce infected red blood cell (RBC) cytoadherence to the vascular endothelium and consequent end-organ dysfunction.

What is etiology of malaria Slideshare?

ETIOLOGY: There are 5 species of plasmodium parasite that can cause malaria in humans: 1. Plasmodium vivax 2. Plasmodium falciparum 3. Plasmodium ovale 4. Plasmodium malariae 5.

What is malaria in PDF?

Malaria is a mosquito-borne infectious disease of humans and other animals caused by. protists (a type of microorganism) of the genus Plasmodium. It begins with a bite from an. infected female mosquito, which introduces the protists via its saliva into the circulatory.

What is the presentation of malaria?

Symptoms of malarial infection are nonspecific and may manifest as a flulike illness with fever, headache, malaise, fatigue, and muscle aches. Some patients with malaria present with diarrhea and other gastrointestinal (GI) symptoms. Immune individuals may be completely asymptomatic or may present with mild anemia.

What pathogens are associated with malaria?

Malaria is caused by protozoa of the genus Plasmodium. Four species cause disease in humans: P falciparum, P vivax, P ovale and P malariae. Other species of plasmodia infect reptiles, birds and other mammals.

What is the pathogenesis of Plasmodium falciparum?

The pathogenesis of human P falciparum infection is a complex interplay of parasite-induced RBC alterations2 and microcirculatory abnormalities,12 accompanied by local and systemic immune reactions, resulting in multiple clinical forms of variable severity.

What is the pathophysiology of malaria in pregnancy?

Malarial infection during pregnancy results into infiltration of the parasite-infected RBCs to the intervillous space of placenta resulting into exacerbated inflammatory response. High inflammation causes oxidative stress-induced apoptotic cell death in the placenta.

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