How do you use Milan criteria?

The Milan criteria, introduced by Mazzaferro in 1996, restrict transplantation in adults with HCC as follows: (1) single tumor diameter less than 5 cm; (2) not more than three foci of tumor, each one not exceeding 3 cm; (3) no angioinvasion; (4) no extrahepatic involvement.

What are the UCSF criteria for liver transplant?

However, an expanded set of criteria proposed by the University of California San Francisco (UCSF), referred to here as the “UCSF” criteria, allows patients with a solitary tumor smaller than 6.5 cm, or patients having 3 of fewer nodules, with the largest lesion being smaller than 4.5 cm or having a total tumor …

What are the requirements for a liver transplant?

Before you can begin the liver transplant evaluation process, you must be free of:

  • Cancer outside the liver.
  • Alcohol for at least 6 months.
  • Substance abuse.
  • Active infections.
  • Disabling psychiatric conditions.
  • Documented medical non-compliance.
  • Lack of adequate social support.
  • Lack of adequate insurance.

What MELD score is required for liver transplant?

When to refer patients with end-stage liver disease. Generally, the liver transplant program at Mayo Clinic in Arizona encourages patients and providers to refer early for transplantation. Though MELD scores 15 and higher are reasonable to initiate referral, Dr.

How do you read a MELD score?

The MELD score ranges from six to 40 and is based on results from several lab tests. The higher the number, the more likely you are to receive a liver from a deceased donor when an organ becomes available.

What is the average wait time for a liver transplant in California?

Advice for patients while waiting An average waiting time for a liver transplant is 149 days for adults and 86 days for children.

How do you calculate MELD?

MELD uses the patient’s values for serum bilirubin, serum creatinine, and the international normalized ratio for prothrombin time (INR) to predict survival. It is calculated according to the following formula: MELD = 3.78×ln[serum bilirubin (mg/dL)] + 11.2×ln[INR] + 9.57×ln[serum creatinine (mg/dL)] + 6.43.

What is MELD score used for?

The MELD score estimates a patient’s chances of surviving their disease during the next three months. Organ allocation is determined by the Organ Procurement and Transplantation Network (OPTN). Livers from deceased donors are allocated to the sickest patients first.

What is the most common indication for liver transplant?

The most common indications for liver transplantation in the United States are hepatitis C virus (30%) and alcoholic liver disease (18%). Other indications include the following: Idiopathic/autoimmune liver disease (12%)