Does granulation improve stability?
Does granulation improve stability?
Melt granulation method could be efficiently applied in order to enhance the stability of moisture sensitive drug and further to improve the poor physical properties of the drug substance.
What are the advantages of dry granulation?
Advantages of dry granulation Dry granulation requires less equipment and minimum floor space. The process eliminates the addition of moisture and allows dry handling of moisture sensitive formulation ingredients. The process is suitable for heat sensitive materials since no drying step is involved.
What is the disadvantages of granulation?
1. Wet granulation often requires several processing steps. 2. The cost of wet granulation is higher because of the time, labour, energy, equipment and space required for the process.
What is high shear granulation?
High shear granulation is a shaping process for granulation that has been enhanced for application in the pharmaceutical industry. A binder liquid is fed to the powder particles in a closed container with blending tools and a chopper. Dense granules are formed through the liquid and solid bridges that result.
Why is granulation important?
Granulation is a key processing step in the production of many solid dosage drugs. It is often necessary to convert powdered drug formulations into a physical form that has improved flow and compaction characteristics to produce tablets with uniform content and consistent hardness and other properties.
How does granulation prevent segregation?
One approach to minimize or even eliminate segregation is wet granulation. The wet granulation process aims to produce granulated additives having similar particle size distributions to the bulk solids so that size segregation can be prevented.
What are the advantages and disadvantages of dry granulation?
4.3 Granulation Process
| Dry Granulation (Roller Compaction) | |
|---|---|
| Advantages | • No introduction of moisture • No introduction of heat • Continuous process |
| Disadvantages | Poor compressibility of drug substance may lead to sticking on rollers |
Is wet or dry granulation better?
The Pharmaceutical dry granulation method Compared to the commonly used practice of Wet Granulation, it is a more economical methodology for granulating powders and is more suitable for using on heat or moisture-sensitive compounds.
What does low shear mean?
Low-shear mixing is a relatively ordered process, meaning that the mixer runs at a low speed and the material’s particles move in an orderly fashion throughout the mixer. For mid-shear mixing, the mixer moves at a slightly higher speed and particles move more randomly around the mixer.
What is low shear viscosity?
Low-shear viscosity is the most often performed test in the control of the coating process. It is a simple test but very useful for determining operation of the coater.
