What is the mechanism of action of clopidogrel?
What is the mechanism of action of clopidogrel?
Mechanism Of Action Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.
What is the role of clopidogrel?
Clopidogrel is in a class of medications called antiplatelet medications. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may cause a heart attack or stroke.
What is the pharmacokinetics of clopidogrel?
In the liver, approximately 15% of absorbed clopidogrel is metabolized by the cytochrome P450 (CYP) system to generate its active metabolite via a 2-step bioactivation process, whereas the rest 85% is hydrolyzed by carboxylesterase 1 (CES1) to an inactive carboxylic acid derivative.
What is the duration of action of clopidogrel?
Clopidogrel
| Clinical data | |
|---|---|
| Onset of action | 2 hours |
| Elimination half-life | 7–8 hours (inactive metabolite) |
| Duration of action | 5 days |
| Excretion | 50% Kidney 46% bile duct |
What class is clopidogrel?
Clopidogrel is an antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.
Is clopidogrel an anticoagulant?
Although they’re used for similar purposes, anticoagulants are different to antiplatelet medicines, such as low-dose aspirin and clopidogrel.
What is clopidogrel used for and side effects?
Clopidogrel is a platelet inhibitor. It reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood. Clopidogrel may also increase the chance of serious bleeding in some people. This medicine is available only with your doctor’s prescription.
Is clopidogrel A anticoagulant?
Anticoagulants, such as heparin or warfarin (also called Coumadin), slow down your body’s process of making clots. Antiplatelets, such as aspirin and clopidogrel, prevent blood cells called platelets from clumping together to form a clot. Antiplatelets are mainly taken by people who have had a heart attack or stroke.
What metabolizes clopidogrel?
Clopidogrel (Plavix) is a prodrug that is metabolized by cytochrome P450 in the liver to an active metabolite that specifically and irreversibly blocks the platelet ADP P2Y12 receptor (as discussed in detail in Chapter 62).
What is another name for clopidogrel?
Clopidogrel oral tablet is available as both a generic and brand-name drug. Brand name: Plavix. Clopidogrel only comes in the form of a tablet you take by mouth. Clopidogrel is used to prevent heart attack and stroke.
What are the contraindications of clopidogrel?
Contraindications / Precautions
- General Information.
- Bleeding, GI bleeding, intracranial bleeding, peptic ulcer disease, surgery, trauma.
- Hepatic disease.
- Renal disease, renal failure, renal impairment.
- Poor metabolizers.
- Epidural anesthesia, labor, obstetric delivery, pregnancy, spinal anesthesia.
- Breast-feeding.
- Geriatric.
