What is actinomycin used for?

A drug that comes from the bacterium Streptomyces parvulus and is used alone or with other drugs to treat adults and children with Ewing sarcoma, gestational trophoblastic tumor, rhabdomyosarcoma, Wilms tumor, or certain types of testicular cancer and adults with certain types of solid tumors.

How does actinomycin work in a cancer cell?

Actinomycin D (ActD), is an anti-neoplastic agent that inhibits RNA synthesis by binding to guanine residues and inhibiting DNA-dependent RNA polymerase [15,16]. ActD is a known DNA-interacting transcription blocker with anti-cancer activity [17,18], working as a cytotoxic inducer of apoptosis against tumor cells [16].

What type of drug is actinomycin?

Dactinomycin is the generic name for the trade name drug Cosmegen®. In some cases, health care professionals may use the trade name Cosmegen or other name Actinomycin-D when referring to the generic drug name dactinomycin. Drug type: Dactinomycin is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.

What is the function of actinomycin D?

Actinomycin D is a well-known antibiotic of the actinomycin group that exhibits high antibacterial and antitumor activity. Actinomycin D has been widely used in clinical practice since 1954 as an anticancer drug for treating many tumors and it is also a useful tool in biochemistry and molecular biology.

What does actinomycin do to bacteria?

It is the most significant member of actinomycin antibiotics, which are isolated from Streptomyces parvulus soil bacteria. It is a compound composed of two cyclic peptides attached to a phenoxazine ring system. It binds to DNA and inhibits RNA transcription.

Is actinomycin used in ectopic pregnancy?

Thoracoscopic excision followed by actinomycin D chemotherapy provided successful resolution of the ectopic pregnancy.

Is actinomycin synthetic or natural?

Actinomycin is the first natural antibiotic discovered that has anti-cancer activity. It was discovered in the bacterium Streptomyces antibioticus in 1940.

How does actinomycin D inhibit transcription?

Actinomycin D is a transcription inhibitor which intercalates into DNA. Actinomycin D forms a very stable complex with DNA, preventing the unwinding of the DNA double-helix, thus inhibiting the DNA-dependent RNA polymerase activity.

What are the side effects of vincristine?

More common

  • Blurred or double vision.
  • difficulty in walking.
  • drooping eyelids.
  • headache.
  • jaw pain.
  • numbness or tingling in fingers and toes.
  • pain in fingers and toes.
  • pain in testicles.

How do you perform a Salpingostomy?

Salpingostomy involves injecting the involved fallopian tube with vasopressin and then creating a linear incision in the area involved with the ectopic pregnancy. The products of conception are then flushed out with a suction-irrigator.