What is DCC used for?

DCC (dicyclohexyl carbodiimide) is one of the most frequently used coupling agents, especially in organic synthesis applications. It has been used for peptide synthesis since 1955 (Sheehan and Hess, 1955) and continues to be a popular choice for creating peptide bonds (Barany and Merrifield, 1980).

What is EDC in organic chemistry?

EDC (also called EDAC) is 1-ethyl-3-(-3-dimethylaminopropyl) carbodiimide hydrochloride, MW 191.70. DCC is N’, N’-dicyclohexyl carbodiimide, MW 206.32. Carbodiimide conjugation, as with CDI-mediated conjugation, works by activating carboxyl groups for direct reaction with primary amines via amide bond formation.

What is EDC NHS chemistry?

EDC/NHS coupling chemistry is commonly used to alter the surface chemistry of NPs with biological molecules to reduce their toxicity [31], [32]. EDC is a water-soluble cross-linker agent, which forms amide bonds between carboxyl and amine groups.

What is DDC chemistry?

Chemistry. Dewey Decimal Classification (DDC)

Is DCC a catalyst?

DCC is produced by the decarboxylation of cyclohexylisocyanate using phosphine oxides as a catalyst: C6H11NCO → (C6H11N)2C + CO. Alternative catalysts for this conversion include the highly nucleophilic OP(MeNCH2CH2)3N.

How do you remove EDC from a reaction?

If it’s water soluble, then go in reverse, wash the crude with base so the EDC becomes organic soluble and get rid of it. If your compound is acid and base sensitive, then maybe try a non-diimide coupling strategy, like mixed anhydride or acid chloride formation.

Is DCC moisture sensitive?

Chemical Properties Moisture Sensitive. Store under Nitrogen. Ambient temperatures. Soluble in methanol, chloroform, dichloromethane, acetonitrile, tetrahydrofuran and dimethylformamide.

Is DCC water soluble?

It is highly soluble in dichloromethane, tetrahydrofuran, acetonitrile and dimethylformamide, but insoluble in water.

How is EDC made?

EDC is made by the direct chlorination or oxychlorination of ethylene. Most EDC plants are integrated with VCM plants. The VCM process generates considerable quantities of hydrogen chloride (HCl), which is then recycled in the oxychlorination process to generate more EDC.