What is the function of 2 deoxy D glucose?

2-Deoxy- d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).

Is 2 deoxy D glucose side effects?

The effect of 2-DG is enhanced in hypoxia, which is a common phenomenon in GBs [8]. Furthermore, 2-DG induces the neuronal commitment of tumor cells [9], inhibits HIF-1α [10] as well as N-linked glycosylation [11], and sensitizes tumors cells to radiation therapy and chemotherapy [12].

How do you make 2 deoxy D glucose?

The preparation method comprises the following steps: taking 3,4,5-tri-O-acetyl D-glucal or 3,4,5-tri-hydroxy-glucal as a raw material, and is placed in a solvent under existence of solid acid, stirring and reacting for certain time under certain temperature, filtering to remove solid acid, washing the solid acid by …

How does 2-deoxyglucose affect ATP production?

Due to its ability to inhibit glycolysis and ATP synthesis, disrupt N-glycosylation of proteins, decrease energy metabolism and NADPH levels, and interfere with cellular thiol metabolism, generating oxidative stress, 2-DG appears to be an efficient cytotoxic agent.

Is D 2 Deoxygalactose the same as d2 deoxyglucose?

Is D-2-deoxygalactose the same chemical as D-2-deoxyglucose? Explain. Both cellulose and glycogen are polymers of D-glucose but they differ in their glycosidic linkage. You just studied 11 terms!

Can diabetic patient take 2 deoxy D glucose?

2-Deoxy-D-glucose uptake was studied in the normal, insulin-treated, and streptozotocin-induced diabetic rat lung. Using an isolated perfused lung preparation, 2- deoxy-o-glucose uptake was enhanced by insulin and depressed by diabetes.

Is 2-deoxyglucose a competitive inhibitor?

Although metrizamide, 2-deoxyglucose, and glucosamine are known to be competitive inhibitors of approximately equal potency for glucose of yeast hexokinase (Ki approximately 0.7 mM for all three), metrizamide is a much weaker competitive inhibitor (Ki about 20 mM) of rat brain hexokinase than either 2-deoxyglucose or …

Can we metabolize D glucose?

2-Deoxy-d-glucose (2-DG) is a stable glucose analogue that is actively taken up by the hexose transporters and phosphorylated but cannot be fully metabolized. 2-DG-6-phosphate accumulates in the cell and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes.

What is the difference between Hemiacetal and glycoside?

Hemiacetal is made by addition of an alcohol to an aldose or ketose. And glycoside is made by condensing hemiacetal with an alcohol.