What is a gastrin secreting tumor?

Zollinger-Ellison syndrome is a rare condition in which one or more tumors form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid.

What causes Zollinger-Ellison syndrome?

Tumors, called gastrinomas, that form mainly in the pancreas and duodenum cause Zollinger-Ellison syndrome. Gastrinomas release large amounts of a hormone called gastrin. Normally, your body releases a small amount of gastrin after you eat, and gastrin triggers your stomach to make acid.

Which cells produce gastrin in pancreas?

[5] Gastrin expressing cells (G-cells) develop from multi-hormonal pre-endocrine cells found in the regenerative isthmus of gastric pits. These pre-endocrine cells undergo asymmetric division, generating a gastrin expressing daughter cell and somatostatin-expressing daughter cell with each division.

Which cells are affected in Zollinger-Ellison syndrome?

As discussed above, Zollinger-Ellison syndrome may occur as a component of the following disorder: Multiple endocrine neoplasia type 1 (MEN-1) is a genetic disorder in which tumors may arise from cells of various endocrine glands, such as the parathyroid glands, the pancreas, and the pituitary gland.

What are the signs and symptoms of Zollinger-Ellison syndrome?

What are the symptoms of Zollinger-Ellison syndrome?

  • Nausea.
  • Vomiting.
  • Weight loss.
  • Diarrhea.
  • Abdominal pain, sometimes burning in nature.
  • Severe heartburn (GERD or gastroesophageal reflux disease)
  • Intestinal bleeding (such as black or tarry stool, or blood in the stool)

How is Zollinger-Ellison diagnosed?

How is Zollinger-Ellison syndrome diagnosed?

  1. Blood tests to look for abnormal levels of gastrin.
  2. Imaging tests, such as a specialized ultrasound called EUS, CT scan, MRI imaging test, or a specialized scan called somatostatin receptor scintigraphy (sometimes called an Octreotide scan).

When should I suspect Zollinger-Ellison?

Diarrhea. Abdominal pain, sometimes burning in nature. Severe heartburn (GERD or gastroesophageal reflux disease) Intestinal bleeding (such as black or tarry stool, or blood in the stool)

What stimulates gastrin secretion?

Gastrin release is also stimulated by the stretching of the stomach walls during a meal, the presence of certain foods (particularly proteins) within the stomach cavity and an increase in the pH levels of the stomach (i.e. the stomach becoming less acidic).

What gland secretes gastrin?

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

Is Zollinger-Ellison syndrome a neuroendocrine tumor?

Zollinger-Ellison syndrome (ZES) is caused by secretion of gastrin by duodenal or pancreatic neuroendocrine tumors (gastrinomas). The annual incidence of gastrinomas is 0.5 to 2 per million population [3-5].

When should you suspect gastrinoma?

The diagnosis of gastrinoma may be suspected in patients with stomach or small intestinal ulcers if they: are resistant to treatment. have recurrent ulcers. have associated complications such as intestinal perforation and bleeding.