What is interface dermatitis?

Interface dermatitis is a histopathological pattern mirroring a distinct cytotoxic immune response shared by a number of clinically diverse inflammatory skin diseases amongst which lichen planus and cutaneous lupus erythematosus are considered prototypic.

How do you get interface dermatitis?

Causes. ID is believed to be caused by a reaction similar to an autoimmune disease, in which your immune system, essentially, misfires. Research suggests that, with interface dermatitis, T cells from the immune system become auto-aggressive.

What causes Lichenoid interface dermatitis?

It is believed that the condition is caused by an allergic reaction to medication or other chemicals, or that it is developed as a result of a viral infection. Many heart disease, high blood pressure, hypoglycemic and arthritis medications are believed to cause an allergic reaction.

Is dermatitis a lupus interface?

Introduction. The 2 main connective tissue disease syndromes characterized by a cell-poor vacuolar interface dermatitis are systemic lupus erythematosus17 and dermatomyositis. 19 Dermatologists apply the designation “acute” lupus erythematosus to the macular erythematous lesions of sudden onset in patients with SLE.

How long does it take for an id reaction to go away?

Most acute id reactions last only 2 to 3 weeks as long as the primary process is treated. Id reactions may be chronic when the stimulus continues (e.g. continued infection of a leg ulcer).

What is connective tissue disease?

A connective tissue disease is any disease that affects the parts of the body that connect the structures of the body together. Connective tissues are made up of two proteins: collagen and elastin. Collagen is a protein found in the tendons, ligaments, skin, cornea, cartilage, bone and blood vessels.

What does an id reaction look like?

Although there are a multitude of varying appearances, the id reaction often presents with symmetrical red patches of eczema with papules and vesicles, particularly on the outer sides of the arms, face and trunk which occur suddenly and are intensely itchy occur a few days to a week after the initial allergic or …

What does lichenoid dermatitis look like?

Lichenoid keratosis typically looks like a small rounded or oval area on the surface of the skin. It can range in size from 3 millimeters to a centimeter or more. It may look like a sore or wart-like growth. It may appear to be inflamed or red, or like a scaly, dry patch on the skin.

Jonathan Cluett, MD, is a board-certified orthopedic surgeon with subspecialty training in sports medicine and arthroscopic surgery. Interface dermatitis (ID) is a reaction characterized by an itchy rash with small, water-filled blisters.

What are the differential diagnoses of a cell-poor interface dermatitis?

The prototypic differential diagnoses of a cell-poor interface dermatitis include erythema multiforme; autoimmune connective tissue disease, particularly systemic lupus erythematosus, dermatomyositis, and mixed connective tissue disease; graft-versus-host disease (GVHD); morbiliform viral exanthem; and morbiliform drug reaction ( Table 1 ).

Is interface dermatitis mononuclear cell-predominant?

This review focuses upon the mononuclear cell-predominant forms of interface dermatitis. The term interface dermatitis refers to the finding in a skin biopsy of an inflammatory infiltrate that abuts or obscures the dermoepidermal junction (DEJ).

What is leukocyte infiltration in interface dermatitis?

Interface dermatitis: diagnostic algorithm. The term “leukocyte infiltration of the dermis” is cumbersome but more generally accurate than inflammation because, in the case of mycosis fungoides, some portion of the infiltrating lymphocytes is neoplastic and not inflammatory in nature.