What are imidazole groups?

Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. For comparison, another group of azoles is the triazoles, which includes fluconazole, itraconazole, and voriconazole.

What is structure of imidazole?

C3H4N2Imidazole / Formula

How many pi electrons does imidazole have?

6 pi electrons
Imidazole is another five-membered heterocyclic ring which has 6 pi electrons and is aromatic.

Is imidazole an amine?

Imidazole: An aromatic amine of molecular formula C3H4N2 having the molecular structure shown below, or a molecule containing this moiety.

Which amino acid has an imidazole group?

Histidine
Histidine, an essential amino acid, has as a positively charged imidazole functional group. The imidazole makes it a common participant in enzyme catalyzed reactions.

Which amino acid contain imidazole group and aromatic ring?

The imidazole/imidazolium ring of histidine is aromatic at all pH values. The acid-base properties of the imidazole side chain are relevant to the catalytic mechanism of many enzymes.

Is imidazole a good leaving group?

to our experimental results. imidazole is a better leaving group, contrary to what we would expected. k2 (n-C4HgNH2) .

How do you calculate the number of pi electrons in a heterocycle?

To count pi electrons, you must consider the number of double bonds and the number of lone pairs in the molecule’s ring. Each double bond has 2 pi electrons. Count how many double bonds there are and then multiply that number by 2. The product is the number of pi electrons in the molecule’s double bonds.

Is imidazole aromatic amine?

Which of the following amino acid contain imidazole moiety?

Five amino acids contribute to this type. The side chains are positively charged; they are lysine, which has a butylammonium side chain, arginine, which has a guanidine group, and histidine, which bears an imidazolium moiety.

What are R groups in amino acids?

Each of the 20 amino acids has a specific side chain, known as an R group, that is also attached to the α carbon. The R groups have a variety of shapes, sizes, charges, and reactivities. This allows amino acids to be grouped according to the chemical properties of their side chains.

What is the basic site of imidazole?

The basic site is the nitrogen with the lone pair (and not bound to hydrogen). Protonation gives the imidazolium cation, which is symmetrical. Imidazole was first reported in 1858 by the German chemist Heinrich Debus, although various imidazole derivatives had been discovered as early as the 1840s.

Which of the following drugs contains an imidazole ring?

Many drugs contain an imidazole ring, such as antifungal drugs and nitroimidazole. Imidazole is a 5 membered planar ring which is soluble in water and polar solvents. Imidazole is a base and an excellent nucleophile.

Why does imidazole exist in two tautomeric forms?

It exists in two equivalent tautomeric forms, because hydrogen can be bound to one or the other nitrogen atom. Imidazole is a highly polar compound, as evidenced by its electric dipole moment of 3.67 D. It is highly soluble in water.

What are the reactants of imidazole?

In one microwave modification, the reactants are benzil, benzaldehyde and ammonia in glacial acetic acid, forming 2,4,5-triphenylimidazole (“lophine”). Imidazole can be synthesized by numerous methods besides the Debus method.