Do thiazide diuretics cause weight gain?
Do thiazide diuretics cause weight gain?
Thiazide diuretics and angiotensin-converting enzyme inhibitors typically cause a transient loss of 1–2 kg body weight in the first 6–8 weeks of therapy secondary to salt and water diuresis. One class of antihypertension medications that does cause true weight gain is the β blockers.
How does thiazide increase calcium reabsorption?
Thiazides enhance Ca reabsorption in the distal convoluted tubule, by increasing Na/Ca exchange (which makes thiazides useful in treating the calcium-subtype of kidney stones).
How do thiazide diuretics increase urine volume?
Diuretic drugs increase urine output by the kidney (i.e., promote diuresis). This is accomplished by altering how the kidney handles sodium. If the kidney excretes more sodium, then water excretion will also increase.
What is the mechanism of action of the different classes of diuretics?
They act by diminishing sodium reabsorption at different sites in the nephron, thereby increasing urinary sodium and water losses. A second class of diuretics, sometimes termed aquaretics, instead inhibit water reabsorption by blocking vasopressin receptors along the connecting tubule and collecting duct.
Do diuretics cause weight gain?
It could be that beta blockers slow your metabolism. Also, if you switch from taking a water pill (diuretic) to a beta blocker as a treatment for high blood pressure, you may gain a few pounds of fluid that the diuretic kept off.
Does diuretic cause weight loss?
Spironolactone works as a diuretic, which means that it causes the body to remove extra fluid. Reducing fluid in the body can result in body weight loss.
Why do thiazide diuretics decrease calcium excretion?
By increasing calcium reabsorption from the luminal membrane into the interstitium in exchange for sodium, thiazides reduce urine calcium levels and increase blood calcium.
How do thiazide diuretics reduce calcium excretion?
Thiazide diuretics are also used upon evidence of bone demineralization if a patient’s diet includes less than the DRI of calcium. Thiazides work by increasing calcium reabsorption at the level of the distal renal tubule and, thus, lowering urinary calcium.
How do diuretic drugs act to increase urine volume?
Diuretics are a class of drugs that increase the flow of urine (termed diuresis). Diuretics work by removing sodium and chloride from the body in the urine, and the sodium and chloride, in turn, draw excess water from the body.
How do diuretics work for weight loss?
Spironolactone works as a diuretic, which means that it causes the body to remove extra fluid. Reducing fluid in the body can result in body weight loss. It’s important to keep in mind that this kind of water-weight loss is not the same as healthy weight loss due to reduction of body fat or body mass.
Does a diuretic make you lose weight?
What are some examples of thiazide diuretics?
What are some examples of thiazide diuretics? Chlorothiazide Hydrocholorthiazide Trichlormethiazide Metolazone. What is the only thiazide diuretic that doesn’t end in thiazide? Metolazone.
Why do thiazide diuretics cause hypokalemia?
because loop and thiazide diuretics increase sodium delivery to the distal segment of the distal tubule, this increases potassium loss (potentially causing hypokalemia) because the increase in distal tubular sodium concentration stimulates the aldosterone-sensitive sodium pump to increase sodium reabsorption in exchange for potassium and hydrogen …
Why are thiazide diuretics used in diabetes insipidus?
– Hypokalemia. Most widely recognized, the first adverse effect of thiazide diuretics is hypokalemia. – Hyponatremia. – Metabolic alkalosis. – Hypercalcemia. – Hyperglycemia. – Hyperuricemia. – Hyperlipidemia. – Sulfonamide allergy.
Can you stop taking a diuretic?
If you take any diuretics (medications that make you urinate more often), ask the healthcare provider performing your procedure what to do. You may need to stop taking them the day of your procedure. Diuretics are sometimes called water pills. Some examples are furosemide (Lasix ®) and hydrochlorothiazide.
