Is atypical Fibroxanthoma benign?

Atypical fibroxanthoma (AFX) is a recently described soft tissue tumour by World Health Organization as a benign tumour of uncertain differentiation, occurring on sun exposed skin in elderly individual [1].

Is atypical Fibroxanthoma a melanoma?

Atypical fibroxanthoma is a diagnosis made histopathologically by ruling out other spindle-cell neoplasms, including spindle-cell SCC (SCSCC), spindle-cell melanoma (desmoplastic melanoma), MFH, leiomyosarcoma, and angiosarcoma.

Is atypical Fibroxanthoma malignant?

Atypical fibroxanthoma (AFX) is an uncommon, pleomorphic, spindle cell cutaneous malignancy that most commonly presents as a solitary red or pink papule or nodule on the head or neck (picture 1A) [1]. Exposure to ultraviolet light most likely contributes to the development of AFX.

Is atypical Fibroxanthoma a sarcoma?

Atypical fibroxanthoma is a rare, low-grade superficial sarcoma that frequently presents as a red nodule or plaque. It is considered a superficial variant of undifferentiated pleomorphic sarcoma (formerly known as malignant fibrous histiocytoma).

What is a benign Fibroxanthoma?

Nonossifying fibroma (fibrous cortical defect, fibroxanthoma) Nonossifying fibroma is a benign fibrous lesion of bone that appears as a well-defined lucent cortical lesion on x-ray. A very small nonossifying fibroma is called a fibrous cortical defect.

What is Fibrosis sarcoma?

Fibrosarcoma is a very rare soft-tissue cancerous tumor, or sarcoma. If you develop fibrosarcoma, you have a soft tissue tumor in the tissues that wrap around your tendons, ligaments and muscles. There are two types of fibrosarcoma: infantile or congenital fibrosarcoma and adult-type fibrosarcoma.

What causes atypical fibroxanthoma?

What causes atypical fibroxanthoma? ยป Atypical fibroxanthoma is associated with prolonged years of sun exposure, aging, and possibly x-ray radiation exposure. Both UV radiation and x-ray radiation can cause abnormal growth of atypical spindle cells, which lead to these growths.

What is Fibroxanthoma in the knee?

Fibroxanthoma of bone is a confusing term that is sometimes used to encompass non-ossifying fibroma and fibrous cortical defect, and at other times synonymously with just non-ossifying fibromas.

What is the survival rate of spindle cell sarcoma?

The five-year sarcoma-specific survival rate was 37%, with no documented improvement over time. Primary metastatic disease was an adverse prognostic factor for survival. Predisposing factors were documented in 19 patients (18%).