Does digoxin affect your kidneys?

Conclusions. In this subset of the DIG trial, digoxin was associated with long term improvement in kidney function, and in patients demonstrating this favorable renal response, reduction in death or hospitalization. Additional research is necessary to confirm these hypothesis generating findings.

Can digoxin cause acute kidney injury?

Digoxin toxicity can present acutely after an an overdose or chronically, as is often seen in patients on digoxin that develop acute kidney injury.

How does digoxin affect urinary output?

No significant changes in serum digoxin were found in this active study. These results are consistent with the hypothesis that increasing glomerular filtration rate or total urine volume increases the renal excretion of digoxin and may result in increased total urinary output of this glycoside.

Is digoxin safe in renal failure?

Digoxin has a small therapeutic-to-toxic margin in patients with CHF (2), particularly in those patients who often have renal dysfunction, and it is therefore logical that, in recent years, numerous physicians have stopped using digoxin for the treatment of patients with CHF on hemodialysis.

How does digoxin affect GFR?

Digoxin efficacy did not differ by level of GFR (P = 0.19 for interaction). Renal dysfunction is strongly associated with mortality in stable outpatients with heart failure, notably in patients with estimated GFR <50 ml/min per 1.73 m(2). The effect of digoxin did not differ by level of renal function.

Why is digoxin contraindicated in renal failure?

In patients with end stage renal failure, mortality increases with increasing serum digoxin levels [20]. The sodium/potassium ATPase pump normally causes sodium to leave cells and potassium to enter cells, blocking this mechanism using digoxin results in higher serum potassium levels.

Why is digoxin no longer recommended?

The use of digoxin is limited because the drug has a narrow therapeutic index and requires close monitoring. Digoxin can cause many adverse events, is involved in multiple drug interactions, and can result in toxicity. Despite its limitations, however, digoxin has a place in therapy.

What drugs should not be taken with digoxin?

Digoxin has many interactions, including:

  • Erythromycin and tetracycline (antibiotics)
  • Antiarrhythmic drugs (amiodarone)
  • Calcium channel blockers.
  • Over-the-counter antacids.
  • Hawthorn (an herbal remedy)
  • Black licorice.
  • Large amounts of oatmeal, milk and high-fibre cereals.

Does digoxin make you pee?

Makes you urinate very frequently. Can cause low levels of important electrolytes, such as potassium.

What are two 2 contraindications for the use of digoxin?

Digoxin is contraindicated in the following conditions[5]: Acute myocardial infarction. Hypersensitivity to the drug. Ventricular fibrillation.

Is digoxin contraindicated in renal failure?

Digoxin is primarily eliminated by the kidney. Patients with renal impairment may be at increased risk for digoxin toxicity, including ventricular arrhythmias and AV conduction disturbances, due to decreased drug clearance. Therapy with digoxin should be administered cautiously in patients with impaired renal function.