What is acantholytic Dyskeratotic Acanthoma?

Acantholytic dyskeratotic acanthoma (ADA) is a rare benign condition characterized by circumscribed epidermal proliferation displaying both acantholysis and dyskeratosis. Most cases are clinically diagnosed as basal cell carcinoma, which leads to their excision and histopathologic examination.

What is acantholytic?

Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders.

What is dyskeratosis histology?

Dyskeratosis is the presence of premature or altered/ abnormal keratinocyte differentiation. Histologically the abnormal keratinocytes have increase/accumulation of keratin filaments leading to a hypereosinophilic cytoplasm (pinker on H&E) and shrunken hyperchromatic nuclei (ie, they are small and dark-staining).

What is acantholytic dermatosis?

Transient acantholytic dermatosis is a self-limited, primary acantholytic disease that occurs predominantly in persons over 50 years old. The primary lesions, discrete papules and papulovesicles, are distributed mainly on the chest, back, and thighs and may be intensely pruritic.

What is Darier disease?

Darier disease, also known as Darier-White disease, keratosis follicularis, or dyskeratosis follicularis (MIM #124200), is a rare autosomal dominant genodermatosis characterized by a persistent eruption of red-brown, keratotic papules scattered to confluent in a seborrheic distribution, nail abnormalities, pitting of …

What is an Acanthoma?

“An Acanthoma is a small, reddish bump that usually develops on the skin of an older adult. There are several types of Acanthoma, including “”acantholytic””, “”epidermolytic””, “”clear cell””, and “”melanoAcanthoma””.

Is clear cell Acanthoma benign?

Clear cell acanthoma is an uncommon type of benign epithelial tumor. Typically, it is a solitary lesion found on the lower limbs. It presents as a nodule or small plaque with slow and well-defined growth.

What is a warty Dyskeratoma?

Warty dyskeratoma (WD) is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. WD presents as an umbilicated papule with a keratotic plug, usually limited to the head, neck, or face.

What’s the definition of dyskeratosis?

[ dĭs-kĕr′ə-tō′sĭs ] n. Premature keratinization in cells that are not in the keratinizing surface layer of the skin. Keratinization of the corneal epithelium.

What are rare Dyskeratotic cells?

Dyskeratosis congenita is a rare genetic form of bone marrow failure, the inability of the marrow to produce sufficient blood cells. Dyskeratosis is Latin and means the irreversible degeneration of skin tissue, and congenita means inborn.

How do you treat acantholytic dermatosis?

The current treatment options include avoidance of exacerbating factors, topical agents (eg, corticosteroids, calcineurin inhibitors, vitamin D analogs), and oral antihistamines. Oral retinoids, methotrexate, and psoralen and ultraviolet A have been used in recalcitrant cases, with various degrees of success.

What is papular acantholytic dyskeratosis of the vulva?

These clinical and histological findings were consistent with the diagnosis of papular acantholytic dyskeratosis of the vulva which is a rare disorder, first described in 1984. Acantholysis / diagnosis Acantholysis / pathology*

What is acantholytic dyskeratosis?

Acantholytic dyskeratosis is an uncommon finding in ‘epidermal nevi’, being present in only 2 of a series of 167 epidermal nevi reported from the Mayo Clinic.937.

What is acantholysis of papillary dermis?

The acantholysis results in suprabasal clefts (lacunae) that contain projections of papillary dermis covered by a single layer of basal cells (villi). There are two types of dyskeratotic cells.

What is transient acantholytic dyskeratosis (Grover’s disease)?

Transient acantholytic dyskeratosis (Grover’s disease) is characterized by multiple small variably pruritic erythematous or skin-colored papules and crusted papulovesicles usually involving the trunk of adults (Fig.