Which are the inhibitors of protein synthesis?

Protein synthesis inhibitors represent another major group of clinically useful antibacterials, such as erythromycin, tetracycline, chloramphenicol, and aminoglycosides. They selectively interact with the 70S bacterial ribosome and spare the 80S eukaryotic ribosome particle.

What does tetracycline do to protein synthesis?

The tetracyclines, which were discovered in the 1940s, are a family of antibiotics that inhibit protein synthesis by preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site.

Which antibiotics are bacteriostatic inhibitors of protein synthesis?

Bacteriostatic inhibitors of protein synthesis: tetracyclines, macrolides, and others

  • Erythromycin.
  • Clarithromycin.
  • Azithromycin.

What are protein synthesis inhibitors and its uses?

A protein synthesis inhibitor is a substance that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. It usually refers to substances, such as antimicrobial drugs, that act at the ribosome level.

What are the inhibitors of transcription?

The Transcriptional Inhibitors, Actinomycin D and α-Amanitin, Activate the HIV-1 Promoter and Favor Phosphorylation of the RNA Polymerase II C-terminal Domain* Actinomycin D and α-amanitin are commonly used to inhibit transcription.

How does erythromycin inhibit protein synthesis?

Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother.

How tetracycline and chloramphenicol inhibit protein synthesis in bacteria?

Mechanisms of Action and Resistance By binding to the 30s portion of the bacterial ribo- some, tetracyclines inhibit protein synthesis by pre- venting access of aminoacyl tRNA molecules to the mes- senger RNA-ribosome-peptide complex (2 I).

Which drugs are bacteriostatic?

[1][2][3][4] The following classes and specific antimicrobials are generally bacteriostatic: tetracyclines, macrolides, clindamycin, trimethoprim/sulfamethoxazole, linezolid, and chloramphenicol.

Is penicillin a protein synthesis inhibitor?

Penicillins have been shown to inhibit bacterial cell wall synthesis, and interact with penicillin binding proteins, leading to bacterial lysis.

Is Penicillin a protein synthesis inhibitor?

How does rifampicin inhibit transcription?

Rifampicin binds to the exit channel of the RNA polymerase by making specific contacts that involve the β-subunit of RNA polymerase. Rifampicin blocks the exit channel thereby inhibiting transcription (Campbell et al., 2001).

Which antibiotic inhibits translation in eukaryotes?

Answer. Fusidic acid is a steroidal antibiotic; in prokaryotes, it inhibits the binding of aminoacyl-tRNA to the ribosome, whereas in eukaryotes, it inhibits translocation by reacting with elongation factor.