Can I take Cipro with Tikosyn?

Interactions between your drugs Using dofetilide together with ciprofloxacin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.

What antibiotics interact with Tikosyn?

Many drugs besides dofetilide may affect the heart rhythm (QT prolongation), including amiodarone, pimozide, procainamide, quinidine, saquinavir, sotalol, macrolide antibiotics (such as clarithromycin, erythromycin), and certain quinolone antibiotics (such as sparfloxacin), among others. (See also Precautions section.)

Is Tikosyn hard on the kidneys?

You should not take Tikosyn if you have severe kidney disease or a history of Long QT syndrome. Serious drug interactions can occur when certain medicines are used together with Tikosyn.

What are some considerations when administering Tikosyn?

TIKOSYN Treatment Guidelines TIKOSYN must be initiated in a setting that provides continuous electrocardiographic (ECG) monitoring and in the presence of personnel trained in the management of serious ventricular arrhythmias. Patients should continue to be monitored in this way for a minimum of 3 days.

What should you not take with dofetilide?

Do not use this medicine together with cimetidine, dolutegravir, hydrochlorothiazide, hydrochlorothiazide/triamterene, ketoconazole, megestrol, prochlorperazine, trimethoprim, trimethoprim/sulfamethoxazole, or verapamil. Using these medicines together may cause serious unwanted effects.

Does dofetilide affect the kidneys?

Geriatric. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dofetilide in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving dofetilide.

Does amoxicillin interact with Tikosyn?

Interactions between your drugs No interactions were found between amoxicillin and Tikosyn. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Does dofetilide cause kidney problems?

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dofetilide in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving dofetilide.

What are the long term side effects of dofetilide?

Less common

  • Chest pain.
  • facial or flaccid paralysis.
  • numbness or tingling of the hands, feet, or face.
  • paralysis.
  • pounding, slow heartbeat.
  • swelling of the ankles, arms, face, feet, fingers, legs, lips, tongue, or throat.
  • troubled breathing.
  • unexplained shortness of breath.

Can you take magnesium with dofetilide?

Two grams of magnesium may be given in addition to dofetilide, and additional doses may be given if necessary.

Does dofetilide increase potassium?

Effects of Dofetilide on Ikr Dofetilide block of IKr increases as extracellular potassium concentration ([K]o) is reduced.

How is Tikosyn metabolized?

Metabolism and Excretion: Approximately 80% of a single dose of dofetilide is excreted in urine, of which approximately 80% is excreted as unchanged dofetilide with the remaining 20% consisting of inactive or minimally active metabolites.