How is Cerezyme made?

Cerezyme® is produced by recombinant DNA technology using mammalian cell culture (Chinese hamster ovary). Purified imiglucerase is a monomeric glycoprotein of 497 amino acids, containing 4 N-linked glycosylation sites (Mr = 60,430).

Is Cerezyme a biologic?

Cerezyme is a biologic therapy that is indicated to treat: pediatric and adult patients with a confirmed diagnosis of Type 1 Gaucher disease that results in one or more of the following conditions: anemia. thrombocytopenia. bone disease.

What natural human enzyme is replaced by Cerezyme?

Clinical manifestations of Gaucher disease type 1 include anemia, thrombocytopenia, hepatosplenomegaly, and skeletal disease. Cerezyme is an analog of the human enzyme β-glucocerebrosidase (also called acid β-glucosidase). Cerezyme reduces the accumulation of GL-1 by cleaving the substrate into glucose and ceramide.

Why is Cerezyme important?

Cerezyme has helped adults and children with Gaucher disease type 1 by improving key disease symptoms over the long term. As with any medicine, there may be potential side effects with Cerezyme. You should notify your doctor immediately if you experience any side effects while undergoing treatment with Cerezyme.

Who manufactures Cerezyme?

Cerezyme is a freeze-dried medicine containing imiglucerase, manufactured by Genzyme Corporation. It is given intravenously after reconstitution as a treatment for Type 1 and Type 3 Gaucher’s disease.

Where is Cerezyme manufactured?

Cerezyme was one of the drugs manufactured at Genzyme’s Allston, Massachusetts plant, for which production was disrupted in 2009 after contamination with Vesivirus 2017.

How much does Cerezyme cost?

The cost for Cerezyme intravenous powder for injection 400 units is around $1,817 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

Who makes Cerezyme?

Where does glucocerebroside come from?

In all cases, typical Gaucher cells, the macrophages containing glucocerebroside, are found in the liver, spleen, lymph nodes, and bone marrow.

What is Cerezyme used for?

Imiglucerase is used to treat a certain rare genetic problem (Gaucher disease). Imiglucerase replaces a certain natural substance (an enzyme called glucocerebrosidase) that is missing in people with Gaucher disease. This medication improves blood, bone, liver, and spleen problems caused by Gaucher disease.