How fast can you infuse oxaliplatin?

Faster FOLFOX: Oxaliplatin Can Be Safely Infused at a Rate of 1 mg/m2/min.

Is oxaliplatin compatible with normal saline?

Oxaliplatin is not compatible with normal saline. Do not piggyback or flush lines with normal saline. Leucovorin dose remains at 400 mg/m2 IV over 2 hours when concurrent oxaliplatin is omitted.

How long does it take to administer oxaliplatin?

You have oxaliplatin as a drip into your bloodstream (intravenously). Each treatment takes between 2 and 6 hours. You can have it through a thin, short tube (a cannula) put into a vein in your arm each time you have your treatment.

What are the contraindications of oxaliplatin?

Oxaliplatin is contraindicated in patients who have/are:

  • Platinum hypersensitivity anaphylaxis[27]
  • Posterior reversible encephalopathy syndrome[30]
  • Grade 3 or 4 peripheral sensory neuropathy[31]
  • Severe renal impairment[32]
  • Chronic lung disease[33]
  • Rhabdomyolysis[34]
  • Sepsis[35]
  • Pregnant or intending to get pregnant[36]

How do you reconstitute oxaliplatin?

Reconstitution. Reconstitute vial containing 50 or 100 mg of oxaliplatin powder with 10 or 20 mL, respectively, of water for injection or 5% dextrose injection to provide a solution containing 5 mg/mL. Must be diluted further before IV administration.

What is the half-life of oxaliplatin?

The distribution half-life of ultrafiltrated plasma platinum ranges from 10 to 25 minutes and its terminal elimination half-life is 26 hours (determined with FAAS) or 270 hours (ICP-MS).

Can oxaliplatin be given peripherally?

During oxaliplatin chemotherapy administration via a peripheral vein, vascular pain requires changing of the intravenous infusion route on occasion. Vascular pain induced by anticancer drugs reduces the rate of patient continuation and completion of chemotherapy.

How often is oxaliplatin given?

This medication is usually given by infusion into a vein over at least 2 hours by a health care professional. It is usually given every 2 weeks along with other medications (such as 5-fluorouracil and leucovorin). The dosage is based on your medical condition, body size, and response to therapy.

Is oxaliplatin a strong chemo?

Oxaliplatin is considered the most neurotoxic chemotherapy, and at the origin of peripheral neuropathies. These neuropathies remain a problem in oncology because currently no prevention strategy has proved effective and only duloxetine seems to have a therapeutic benefit in improving symptoms.

What is one unique side effect of oxaliplatin?

Oxaliplatin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

How can I reduce the side effects of oxaliplatin?

Other ways to reduce the side effects caused by cold: Cover yourself with a blanket while you receive your Oxaliplatin infusion. Do not breathe deeply when exposed to cold air. Wear warm clothing in cold weather at all times.

What is oxaliplatin injection?

Oxaliplatin is used with other medications to treat advanced colon or rectal cancer (cancer that begins in the large intestine). Oxaliplatin is also used with other medications to prevent colon cancer from spreading in people who have had surgery to remove the tumor.