What is difference between FFP and PCC?

FFP is the standard of care in the United States ; however, FFP needs to be given in a dose of 15-20 mL/kg and therefore requires a large-volume infusion. PCC contains high levels of vitamin K-dependent cofactors and thus involves a smaller-volume infusion than FFP and more rapid administration.

What is Octaplex?

Octaplex belongs to a group of medicines called clotting factors. It contains the human vitamin K dependent blood coagulation factors II, VII, IX and X. Octaplex is used to treat and prevent bleeding: • caused by medicines called vitamin K antagonists (such as warfarin).

What is the difference between FFP and plasma?

Plasma is the liquid part of blood. It contains water, minerals, and other substances. Fresh frozen plasma (FFP) is plasma that has been frozen so it can be stored and used later. The plasma you get is thawed out and warmed before it is used.

What is the difference between cryo and FFP?

FFP is indicated when a patient has MULTIPLE factor deficiencies and is BLEEDING. Note that FFP SHOULD NEVER be used as a plasma expander. Cryoprecipitate (cryo) contains a concentrated subset of FFP components including fibrinogen, factor VIII coagulant, vonWillebrand factor, and factor XIII.

Is PCC same as cryoprecipitate?

Prothrombin complex concentrate (PCC) comes from the process of ion-exchange chromatography from the cryoprecipitate supernatant of large plasma pools and after removal of antithrombin and factor XI.

When should I take Octaplex?

In patients with acquired deficiency of the vitamin K dependent coagulation factors (e.g. as induced by treatment with vitamin K antagonists), Octaplex should only be used when rapid correction of prothrombin complex levels is necessary, such as major bleeding or emergency surgery.

Why is Octaplex used?

Octaplex is a new prothrombin complex concentrate that is indicated for treatment or perioperative prophylaxis of bleeding in patients with deficiency of the prothrombin complex coagulation factors, such as deficiency caused by treatment with vitamin K antagonists or by liver failure, when rapid correction of bleeding …

Is fresh frozen plasma same as plasma?

WHAT IS THE DIFFERENCE BETWEEN FRESH FROZEN PLASMA AND PLASMA? Fresh Frozen Plasma contains all blood clotting factors including the heat labile Factors V and VIII. Plasma contains all blood clotting factors with reduced amount of the heat labile Factors V and VIII.

Why is fresh frozen plasma given?

Fresh frozen plasma is used for management and prevention of bleeding, as a coagulation factors replacement, and to treat thrombotic thrombocytopenic purpura (TTP). Fresh frozen plasma is available under the following different brand names: FFP and Octaplas.

When is Cryo preferred over FFP?

Cryoprecipitate is preferred because it contains the same concentration of fibrinogen as FFP in less than one-twentieth of the volume. For example, the concentration of fibrinogen is approximately 1500 mg/dL in cryoprecipitate and 100-300 mg/dL in plasma.

Why do we give cryoprecipitate?

Cryo is used to prevent or control bleeding in people whose own blood does not clot properly. This includes patients with serious but rare hereditary conditions such as Hemophilia A (who lack factor VIII) and von Willebrand disease (who lack von Willebrand factor).