What is plasmin What is its function?

Plasmin is an autologous serum protease that is a key component of the fibrinolysis cascade. Plasmin is a non-specific protease usually present in human serum, and it is responsible for degrading a variety of plasma proteins; its specific physiologic role is to degrade fibrin clots.

What is the role of plasmin in the clotting process?

Plasmin functions in the fibrolytic mechanism to dissolve blood clots, whether formed normally in cases of injury or abnormally in cases of thrombosis. Plasmin levels must be carefully regulated; increased levels of plasmin may result in excessive bleeding and decreased levels of plasmin may result in thrombosis.

What is the effect of plasmin?

Plasmin causes the degranulation of platelets; subsequently, ADP released from granules plays a crucial role in the induction of platelet aggregation.

What does plasmin break down?

Plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other proteases. Primary fibrinolysis is a normal body process. Secondary fibrinolysis is the breakdown of clots due to medicine, disorder, or other cause.

Where is Fibrinolysin produced?

Fibrinolysin is an enzyme derived from plasma of bovine origin (plasmin) or extracted from cultures of certain bacteria. It is used locally only and exclusively together with the enzyme desoxyribonuclease (extracted from bovine pancreas).

What is Elase used for?

BRAND NAME(S): Elase. USES: This medication breaks up and helps remove dead skin and tissue to encourage healing of wounds. It is used to promote healing of wounds such as burns, ulcers, surgical wounds, circumcision or episiotomy.

How does plasmin inhibit platelet aggregation?

These results suggest that plasmin inhibits platelet function, at least in part, by blocking the mobilization of arachidonic acid from membrane phospholipid pools.

Where is plasmin produced?

A Plasmin(ogen) The majority of plasminogen is produced in the liver, but a number of sites of extrahepatic synthesis have also been reported. The plasma concentration of plasminogen is relatively stable, at approximately 200 mg per L or 2 μM, but an increase is observed during the acute-phase response.

How is plasmin regulated?

Plasmin has a central role in the regulation of the inflammatory response via MMP9 activation. Administration of CpG/DG activates TLR-9 in different cell populations, which stimulates the secretion of urokinase-type plasminogen activator that will modify plasminogen into its active form, plasmin.