Does gentamicin follow linear kinetics?

Gentamicin elimination follows exponential — not linear — decay, and because of this, the trough level for once/day dosing should be far less than the trough for 3 times/day.

What is aminoglycoside in pharmacology?

Aminoglycosides are potent bactericidal antibiotics that act by creating fissures in the outer membrane of the bacterial cell. They are particularly active against aerobic, gram-negative bacteria and act synergistically against certain gram-positive organisms.

What is the mechanism of aminoglycosides?

The mechanism of action of aminoglycosides depends on the inhibition of polypeptide synthesis. In fact, some of them such as Streptomycin, Sisomicin and Gentamicin are believed to cause codon misreading, by increasing the incorporation of certain aminoacids into polypeptide in the ribosome-polyribonucleotide system.

Are aminoglycosides narrow or broad-spectrum?

The aminoglycosides are broad-spectrum, bactericidal antibiotics that are commonly prescribed for children, primarily for infections caused by Gram-negative pathogens. The aminoglycosides include gentamicin, amikacin, tobramycin, neomycin, and streptomycin.

Do aminoglycosides follow linear kinetics?

Aminoglycosides exhibit linear kinetics…just like vancomycin! Recall that this means a change in dose will produce a proportional change in serum concentration. It also means that a constant proportion of drug is eliminated over time.

Which drugs follow first order kinetics?

A few substances are eliminated by zero-order elimination kinetics, because their elimination process is saturated. Examples are Ethanol, Phenytoin, Salicylates, Cisplatin, Fluoxetin, Omeprazol….

Elimination kinetics First order Zero order
Term in clinical pharmacology Linear kinetics Non linear kinetics

Are aminoglycosides narrow or broad spectrum?

Why gentamicin is a broad spectrum?

Gentamicin is bacteriocidal and is broad spectrum except for streptococci and anerobic bacteria. Its mechanism of action inhibits bacterial protein synthesis by binding to 30S ribosomes. Historically, gentamicin has been used for acute serious infections, such as those caused by gram-negative bacteria.

Is gentamicin broad or narrow spectrum?

Introduction. Gentamicin is a parenterally administered, broad spectrum aminoglycoside antibiotic typically used for moderate to severe gram negative infections. Despite its wide use, gentamicin has not been definitively linked to instances of clinically apparent liver injury.