Why is cilastatin added to imipenem?

Why is cilastatin added to imipenem?

Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin (sye” la stat’ in), a DHP-I inhibitor which increases half-life and tissue penetration of imipenem.

Is imipenem and cilastatin the same?

Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors. It works by helping imipenem stay active in your body for a longer period of time.

What is cilastatin mechanism?

Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.

Is cilastatin an antibiotic?

Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, cilastatin in and of itself does not have any antibacterial activity.

Is it important to give cilastatin with other carbapenems?

Other carbapenems do not require coadministration with cilastatin because they are not metabolized by dipeptidase. Doses must be reduced in patients with renal dysfunction.

Is cilastatin a beta lactamase inhibitor?

Conclusion: Imipenem/cilastatin/relebactam is a new β-lactam/β-lactamase inhibitor combination with activity against MDR gram-negative bacteria, including many CRE but excluding MBL-producing Enterobacterales and carbapenem-resistant Acinetobacter baumannii.

What class of antibiotic is imipenem?

Abstract. Imipenem, the first of a new class of carbapenem antibiotics, has potent activity against most clinically important species of bacteria, including isolates resistant to other antibiotics.

Is imipenem a strong antibiotic?

Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus play a key role in the treatment of infections not readily treated with other antibiotics….Imipenem.

Why are carbapenems administered with cilastatin?

Carbapenems are administered via IV. Carbapenems are eliminated by the kidneys. Imipenem is hydrolyzed by renal tubular dipeptidase. Imipenem is therefore always combined with cilastatin, which inhibits this breakdown.

Is cilastatin a beta lactam?

Imipenem/cilastatin/relebactam is a new β-lactam/β-lactamase inhibitor combination with activity against MDR gram-negative bacteria, including many CRE but excluding MBL-producing Enterobacterales and carbapenem-resistant Acinetobacter baumannii. It is approved for the treatment of cUTIs, cIAIs, and HABP/VABP.

What are the side effects of imipenem?

Swelling, redness, pain, or soreness at the injection site may occur. This medication may also rarely cause upset stomach, nausea, vomiting, or diarrhea. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

What is the nickname for imipenem?

Imipenem/cilastatin