Which pigment produced by Pseudomonas aeruginosa is responsible for the blue green color of infected wounds?

Genus Pseudomonas produces a variety of extra-cellular pigments of which phenazines comprise the most significant one. The most characteristic feature of Pseudomonas aeruginosa is the production of soluble pyocyanin pigment: a water soluble blue green phenazine compound.

What are Phenazines used for?

Phenazines serve as electron shuttles to alternate terminal acceptors, modify cellular redox states, act as cell signals that regulate patterns of gene expression, contribute to biofilm formation and architecture, and enhance bacterial survival.

Is pyocyanin a pigment?

Pyocyanin is a blue pigment synthesized by about 95% of the strains of Pseudomonas aeruginosa.

Is pyocyanin a toxin?

Pyocyanin (PCN−) is one of the many toxic compounds produced and secreted by the Gram negative bacterium Pseudomonas aeruginosa. Pyocyanin is a blue (turning red below pH 4.9), secondary metabolite with the ability to oxidise and reduce other molecules and therefore kill microbes competing against P.

Is Pseudomonas aeruginosa resistant to antibiotics?

aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics.

What antibiotics work against Pseudomonas aeruginosa?

Pseudomonas infection can be treated with a combination of an antipseudomonal beta-lactam (eg, penicillin or cephalosporin) and an aminoglycoside. Carbapenems (eg, imipenem, meropenem) with antipseudomonal quinolones may be used in conjunction with an aminoglycoside.

Is Phenazine an antibiotic?

Abstract. Phenazines are natural bacterial antibiotics that can protect crops from disease.

What are two genera of bacteria that produce antibiotics?

The bacterial genera Bacillus and Streptomyces along with the fungal genera Penicilium and Cephalosporium are commonly found in soil. The genus Streptomyces are the most prolific antibiotic producers and, although bacteria, are a unique subgroup of bacteria called the Actinomycetes.

Is pyocyanin a virulence factor?

Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems.

What causes pyocyanin?

Pyocyanin is produced in large quantities in low iron-containing media and helps with iron metabolism in the bacterium. Infections caused by P. aeruginosa are suppurative as a result of secretion of this pigment (derived from ‘pyocyaneus’ or ‘blue pus’) at the site of infection.

What antibiotics are sensitive to Pseudomonas?

The organism is usually sensitive to imipenem, penicillin, doxycycline, azlocillin, ceftazidime, ticarcillin-clavulanic acid, and ceftriaxone. Initiate treatment early in the course of the disease. The organism is resistant to ciprofloxacin and aztreonam.

What is the drug of choice for Pseudomonas?

Ceftazidime is the antibiotic of choice because of its high penetration into the subarachnoid space and the high susceptibility of Pseudomonas to this drug. Initial therapy in critically ill patients should include an intravenous aminoglycoside.