What is Higuchi model in drug release?

Simplified Higuchi model describes the release of drugs from insoluble matrix as a square root of time dependent process based on Fickian diffusion Equation. The data obtained were plotted as cumulative percentage drug release versus square root of time. The slope of the plot gives the Higuchi dissolution constant KH.

How do you measure drug release from nanoparticles?

To measure drug release from nanoparticles, nanoparticles should be lyophilized, weighed, and resuspended in buffer (I used two different PBS/0.1% Tween-80 buffers, one at pH 7.4 and one at pH 6.5, but you can use what ever buffer is suitable for your drug/nanoparticle preparation) and then incubate in a 37 °C water …

How is drug release kinetics calculated?

The fundamental principle for evaluation of the kinetics of drug release was offered by Noyes and Whitney in 1897 as the equation (10): dM/dt = KS (Cs с Ct) (1) where M, is the mass transferred with respect to time, t, by dissolution from the solid particle of instanta- neous surface, S, under the effect of the …

What is the mechanism of drug release?

There are many mechanisms by which the drug release can be controlled in a system: dissolution, diffusion, osmosis, partitioning, swelling, erosion, and targeting. They are dependent on the particular application and may act simultaneously or at different stages of a process of delivery.

Which one is the Higuchi model equation?

Higuchi equation – Higuchi-Gleichung In its simplified (“classical” ) form, the Higuchi equation reads: M t A = 2 C 0 D C s t {\displaystyle {\frac {M_{t}}{A}}={\sqrt {2\ C_{0}\ D\ C_{s}\ t}}} the saturation concentration in the matrix material.

What is a drug release test?

The drug release testing method is important for the characterization of dosage form performance under in vitro standardized conditions and can provide insight into the in vivo performance of the drug product.

What is a suitable dissolution method for drug nanoparticles?

Dissolution via dialysis was rate-limited by the membrane. Conclusions: The data showed the flow-through cell to be unequivocally the most robust dissolution method for the nanoparticulate system.

What is the Noyes Whitney equation?

2.3. The dissolution rate of a solid in solvent is written by Noyes–Whitney equation, as follows,(1) dC dt = DS w Vh ( C s − C ) , where C and Cs represent the concentration of the dissolved substance at a given time t and the solubility concentration of the substance, respectively.

How do you calculate cumulative drug release?

Put the absorbance data of the samples (collected at predetermined time) into the standard curve of the drug. Then divide the obtained value to total amount of the drug encapsulated in the NPs and multiply with 100, you will obtain cumulative drug release at that time interval.