What is the role of natriuretic peptides?

Atrial natriuretic peptide (ANP) and brain (B-type) natriuretic peptide (BNP) are circulating hormones of cardiac origin that play an important role in the regulation of intravascular blood volume and vascular tone.

What are the effects of natriuretic peptides?

These peptides cause effects such as diuresis, natriuresis, vasodilation, and inhibition of aldosterone synthesis and renin secretion as a circulating hormone, and thereby play an important role in regulating blood pressure and blood volume (Table 1).

What do natriuretic hormones do?

Natriuretic hormones (NH) are compounds that act in an endocrine or paracrine fashion to regulate extracellular fluid volume and blood pressure (BP) through the stimulation of sodium excretion by the kidney.

What happens if you have too much ANP?

This leads to a change in plasma protein osmotic pressure, which causes an expanded plasma volume. A chronically increased vascular volume and increased ventricular filling could account for increased cardiac output, the development of hypertension, and cardiac hypertrophy as has been observed.

What is natriuretic action?

Natriuresis is the process of sodium excretion in the urine through the action of the kidneys. It is promoted by ventricular and atrial natriuretic peptides as well as calcitonin, and inhibited by chemicals such as aldosterone.

What is the function of Neprilysin?

Neprilysin (NEP) is an integral membrane-bound metallopeptidase with a wide spectrum of substrates and physiological functions. It plays an important role in proteolytic processes in the kidney, cardiovascular regulation, immune response, cell proliferation, foetal development etc.

What is the action of natriuretic peptides quizlet?

A peptide secreted by the cardiac atria that promotes salt & water excretion & lowers BP. Powerful Vasodilator.

What is a neprilysin inhibitor?

Neprilysin inhibitors are a new class of drugs used to treat high blood pressure and heart failure. They work by blocking the action of neprilysin thus preventing the breakdown of natriuretic peptides.

What stimulates ANP release?

The most potent stimulus for release of ANP is atrial stretch, the consequence of abnormally high circulating blood volume. The desired physiologic response to normalize this condition is to enhance elimination water and sodium in urine.

What is a natriuretic peptide secretion?

Natriuretic peptides (NPs) are produced and stored in the heart, both in the atria and ventricles, and released from the heart due to abnormal stretch in response to pressure changes and volume overload in the heart.

What stimulates natriuretic peptide release?

Natriuretic peptides (NPs) are peptide hormones that are synthesized by the heart, brain and other organs. The release of these peptides by the heart is stimulated by atrial and ventricular distension, as well as by neurohumoral stimuli, usually in response to heart failure.