What is MUC1 protein?

Normal Function. Collapse Section. The MUC1 gene provides instructions for making a protein called mucin 1. This protein is one of several mucin proteins that make up mucus, a slippery substance that lubricates and protects the lining of the airways, digestive system, reproductive system, and other organs and tissues.

Is MUC1 a glycoprotein?

Mucin-1 (MUC1) is a transmembrane glycoprotein with extensive O-linked glycosylation of its extracellular domain. MUC1 presents on the apical surface of epithelial cells of the lung, stomach, intestines, eyes, and a variety of hematopoietic cells [118,119].

Is MUC1 a protein?

MUC1 has a core protein mass of 120-225 kDa which increases to 250-500 kDa with glycosylation. It extends 200-500 nm beyond the surface of the cell. The protein is anchored to the apical surface of many epithelia by a transmembrane domain.

Where is MUC1 expressed?

MUC1 structure and expression. The MUC1 gene encodes a type-I transmembrane glycoprotein that is expressed on the apical surface of most simple epithelia, including mammary gland, female reproductive tract, lung, kidney, stomach, gall bladder, and pancreas as well as some non-epithelial cell types [reviewed in [1]].

What is mucin production?

Mucin glycoproteins produced by mucus-producing cells in the epithelium or submucosal glands are the major macromolecular constituent of mucus and are responsible for the viscous properties of the mucus gel.

What does EMA negative mean?

Normal results are negative, meaning that no EMA antibodies were found in your blood. If your levels of IgA EMA and tTG antibodies are higher, it may mean that you have celiac disease. If you also have typical symptoms and respond to a gluten-free diet, you will likely be diagnosed with celiac disease.

Is mucin cancerous?

Mucinous carcinoma is an invasive type of cancer that begins in an internal organ that produces mucin, the primary ingredient of mucus. The abnormal cells inside this type of tumor are floating in the mucin, and the mucin becomes a part of the tumor.