Is weight loss a side effect of zonisamide?

Weight loss was an adverse effect associated with zonisamide treatment in epilepsy clinical trials.

Does Zonegran increase metabolism?

Effects of other drugs on ZONEGRAN pharmacokinetics: Drugs that induce liver enzymes increase the metabolism and clearance of zonisamide and decrease its half-life.

Why does zonisamide make you lose weight?

How does Zonegran help me lose weight? Zonegran increases monoamines, which suppress the NPY and AgRP neurons in the hypothalamus that stimulate the appetite. Zonegran may also stimulate the pro-opiomelanocortin receptors in the hypothalamus which suppress the appetite.

How fast does zonisamide work for weight loss?

Zonisamide is an antiepileptic drug that demonstrated weight loss efficacy in obese adults(−5.9 kg vs −0.9 kg) in a 16-week trial with further weight loss in the additional 16-week extension phase.

Does zonisamide increase metabolism?

Furthermore, zonisamide does not induce its own metabolism and does not induce liver enzymes. However, since zonisamide is metabolized by cytochrome P450, liver enzyme-inducing AEDs will increase zonisamide clearance, and dosage adjustments may be necessary when it is used in combination with certain AEDs.

Which is better for weight loss topiramate or zonisamide?

Weight reduction was not statistically different between topiramate or zonisamide. Anticonvulsants were associated with an increase in body mass index, yet the benefits of the two anticonvulsants on weight loss remained despite the counteractive effects of antipsychotics.

Is zonisamide a diet pill?

How long does it take to lose weight on Zonegran?

In the first study, obese people lost 13 pounds after 16 weeks of adding the epilepsy drug Zonegran to a low-calorie diet. In the second study, the optimal dose of the experimental drug Axokine helped obese people lose nine pounds in 12 weeks.

How do you lose weight on zonisamide?

The antiepileptic drug zonisamide, at a dosage of 400 mg per day, is associated with enhanced weight loss for obese patients when combined with diet and lifestyle counseling, but the incidence of adverse events is high, according to a study published online Oct.