Which chemotherapy drugs are cardiotoxic?
Which chemotherapy drugs are cardiotoxic?
The most common chemotherapy drugs related to cardio-toxicity include:
- 5-fluorouracil (Adrucil)
- Paclitaxel (Taxol)
- Anthracyclines (a class of drugs)
- Targeted therapies: such as monoclonal antibodies and tyrosine kinase inhibitors.
- Some Leukemia drugs.
What does cardiotoxic mean?
Cancer drugs and treatments can cause direct damage to the heart. This is known as cardiotoxicity.
What are the symptoms of cardiac toxicity?
Symptoms of cardiac toxicity may include:
- Chest pain.
- Heart rhythm changes (arrhythmia).
- Fatigue.
- Shortness of breath.
- Weight gain.
- Swelling.
Is chemotherapy induced cardiomyopathy reversible?
It is often reversible after treatment discontinuation and can be tolerated once again, if indicated, after recovery (10). The risk of developing trastuzumab cardiotoxicity increases in patients who receive concurrent anthracycline therapy especially if the cumulative doxorubicin dose is > 300 mg/m².
What is the most toxic chemotherapy drug?
Direct pairwise meta-analysis results also revealed that the gemcitabine + carboplatin chemotherapy regimen was the most toxic regimen in hematologic for AOC patients among 8 chemotherapy regimens.
What is the Red Devil chemo?
The chemotherapy (“chemo”) drug “The Red Devil” is doxorubicin (Adriamycin). It is an intravenous cancer medicine with a clear, bright red color, which is how it got its nickname.
Can you reverse cardiotoxicity?
Trastuzumab-related cardiotoxicity may be reversible upon treatment cessation or appropriate management with cardiac therapy. The management of patients with trastuzumab-induced LVD is controversial.
How do you treat cardiotoxicity?
The most common medications used for cardiotoxicity treatment include: Beta-blockers, which slow down a patient’s heart rate, lower a patient’s blood pressure and strengthen the heart muscle can reduce palpitations and arrhythmias, hypertension and heart failure.
Can chemo weaken your heart?
Some types of chemotherapy (primarily in a class of drugs called anthracyclines) weaken the heart muscle from a buildup of calcium and other chemical reactions in the body that release harmful free radicals. Thus, chemotherapy side effects include cardiomyopathy (an enlargement) or congestive heart failure.
How can I protect my heart during chemo?
Stay healthy after treatment
- Get to and stay at a healthy weight.
- Get regular exercise.
- Eat a healthy diet, with an emphasis on fruits, vegetables, and whole grains.
- Get recommended cancer screenings.
- Create a survivorship care plan.
- Keep your follow-up appointments.
- Take care of your emotional health.
What is the Red Devil in chemotherapy?
Can chemo cause damage to heart?
Traditional and novel chemotherapy agents can damage the heart or peripheral blood vessels, or cause problems with clotting or blood lipids. Some serious cardiovascular effects occur while the chemotherapy is being given; others appear long after cancer has become a distant memory.
